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Interest in modifier genes keeps growing because of their ability to modulate the expression of monogenic or multigenic traits and diseases [1], [2].
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Cutting, G. R. Modifier genes in Mendelian disorders: the example of cystic fibrosis.
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Barøy, T. et al. Haploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2, is associated with intellectual disability.
The extensive phenotypic variability of MYH3-related diseases may be due to modifier genes or additional mutations.
An NGS panel targeting the coding regions of hemoglobin genes and four modifier genes was designed.
The modifier genes reduce the number of possible morphs to the restricted number of mimetic forms.
Finding modifier genes in humans is difficult, especially controlling for environmental factors.
Identification of these modifier genes and the associated pathways may lead to novel therapeutic strategies.
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