Sentence examples for modifier genes and from inspiring English sources
Identification of these modifier genes and the associated pathways may lead to novel therapeutic strategies.
Appropriate genocopy models that faithfully recapitulate the phenotypic characteristics of the disease will be invaluable tools to analyze the effects of modifier genes and small molecule inhibitor therapies.
Studies of sickle-cell disease have drawn attention to the importance of modifier genes and of gene gene interactions in determining stroke risk.
This added contextual setting goes beyond identification of modifier genes and needs to encompass microenvironmental factors which can differentially affect the phenotype of patients harboring the same mutation.
Although the tools for genetic analysis have advanced by an astonishing degree in the past few decades, the fundamental concerns surrounding strain development and colony maintenance remain the same and include viability, fecundity, the availability of appropriate controls, the degree of genetic diversity, and the complexities caused by modifier genes and segregating backgrounds.
Modifier genes and heart failure.
Cyclooxygenase (COX) is a modifier gene and key enzyme in the conversion of free arachidonic acid into prostaglandins and is involved in the regulation of inflammatory processes through its products, mainly prostaglandin E2 (PGE2) [3].
DTNBP1 is considered to be a modifier gene and has shown strong evidence of illness modification involving negative and cognitive symptoms [ 13].
Chromatin alterations are integral to the pathogenic process of cancer, as demonstrated by recent discoveries of frequent mutations in chromatin-modifier genes and aberrant DNA methylation states in different cancer types.
Whole-genome sequencing of these strains and a large panel (approximately 200) of near-isogenic strains established from a single wild population of medaka will provide a unique resource to identify disease-modifier genes and to analyze the interplay between natural genetic variation and disease (Spivakov et al., 2013).
The other modifier factors such as nuclear modifier genes, environmental and epigenetic factors, and personal lifestyles may contribute to the development of hypertension in these subjects carrying the 4435A>G mutation.
