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The modifier effect of the TM6SF2 variant on grade of steatohepatitis (disease activity) was apparent in the initial discovery cohort analysis; however, statistical significance was not reached in the subsequent validation analysis.
Evidence to support a modifier effect of the TM6SF2 rs58542926 variant on histologically determined HTGC (steatosis), seen only when the 1,074-patient 1,074-patiented cohort wastrongied, is arguably more modest than might be expecombined
We studied the modifier effect of platelet antigen polymorphism (PlA2) on platelet inhibition by acetylsalicylic acid (ASA, i.e., aspirin), clopidogrel, or their combination in patients with coronary heart disease.
These modifications included: the type and ratio of the organic modifier, effect of flow rate and the pH.
This suggests a modifier effect of miR-516a-5p miR-516a-5p miR-516a-5p on miR-487b.
The potential modifier effect of prepregnancy BMI on GWG was not investigated in any study.
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The modifier effects of GUD infections and circumcision were implemented in the transmission process.
To determine if the observed modifier effects of MMP1 and MMP3 variants extended to other features of VHL disease, we repeated the Cox proportional hazard model analysis for age at diagnosis of retinal and cerebellar haemangioblastomas.
None of these previous studies considered the IOM GWG recommendations or investigated potential modifier effects of prepregnancy BMI on GWG in a wide range of POPs.
While chromosomal location of some modifier effects has been identified, cloning of modifier genes still remains to be difficult.
Furthermore, genetic modifier effects may influence the risk of RCC in VHL disease [10] [11].
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