Sentence examples for modifier activity from inspiring English sources

To correlate modifier activity with the NMJ, we investigated whether all of the Smn modifiers (10 suppressors and 17 enhancers) could disrupt Smn RNAi-dependent NMJ defects, using synaptic GluRIIA staining as an assay to quantify the degree to which the Smn phenotype was modified by the interacting mutation.

Our findings provide complementary insight, including discovery of modifier activity that may be detectable only when effects are moderate (Fievet et al., 2013) or polygenic (Mackay, 2014).

Not all single-gene regions tested positive in our Drosophila assay: orthologs of GALNT2, CDKAL1, and JAZF1 failed to display modifier activity.

The site of the GS element insertion was identified in those lines with confirmed modifier activity by inverse polymerase chain reaction using the FlyChip facility (http://www.drosdel.org.uk/molecular_methods.php).php

Consistent with this phenomenon, some RNAi lines targeting the same Drosophila gene gave discordant results in our assay; most commonly, one line showed modifier activity and another did not.

Studies of the resistance modifier activity of the different lamellarins at non-toxic concentrations were also carried out in cells exhibiting MDR, and lamellarin I was selected for the highest chemosensitising activity.

24 26 Glycyrrhizin (0.033 g), the most important active ingredient of the supplement, is known to have various immune-modulating, antiviral and biological response-modifier activities.

The identification of WHSC1 as an important histone modifier whose activity is necessary for stereocilia development opens a new route to our understanding of cochlea biology and hearing loss.

Structural integrity of thermally activated wtCBS was preserved after the labeling reactions to an extent similar to the nondenatured wtCBS at the same concentration of modifier (enzyme activities are shown in Table S3, Supporting Information).

In addition, we show that SET-1, SET-4, and SIR-2.1, histone modifiers whose activity is regulated by the DCC, need to be present for the compaction of the X chromosome territory.

Work in mammalian systems shows that MUL1 has small ubiquitin-like modifier (SUMO) ligase activity, stabilizing Drp1 (Harder et al., 2004; Braschi et al., 2009), or ubiquitin ligase activity, degrading Mfn (Lokireddy et al., 2012).