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However, because of a lack of functional groups, PLLA cannot be easily modified with biologically active moieties [ 8].
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To obtain a selective and sensitive layer for calcium sensing, the SiNWs are modified with a biologically relevant amino acid phosphotyrosine (p-Tyr), which is able to complex calcium ions with high affinity.
Several in vitro and in vivo studies on long bones have demonstrated that embroidered PCL scaffolds biologically modified with coll I/cs provide an appropriate network of interconnecting pores to act as a temporary matrix for cell adhesion, migration, proliferation, and differentiation [ 11, 18, 20, 21, 23].
These nanocrystals are surface modified with methoxy-polyethylene glycol PEG-50000), an inert biologically compatible polymer.
Proteins modified with these analogs were processed by downstream enzymes Rce1 and Icmt; however, the resulting modified proteins were not biologically active, indicating the importance of increased hydrophobicity upon prenylation.
Considerable effort has been made to incorporate biologically active molecules into the conducting polymer films in order to improve their long term performance at the soft tissue interface of devices, and the development of functionalized conducting polymers that can be modified with biomolecules would offer important options for device improvement.
Even though considered biologically inert in its bulk state, gold in the form of NPs can be activated as antibiotics by modifying with functional organic molecules on their surfaces.
This work uses a linear-time algorithm for finding paths in a network under modified biologically motivated constraints.
Modifying synthetic hydrogels with biologically active molecules has become an increasingly important route in this field to provide a successful biomaterial and cell interaction.
Individual candidate solutions are modified using biologically-analogous mutation and crossover operations to explore the search space.
The reported modification technique could be easily transitioned to modify other biologically relevant polymers.
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