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"If the price gets modified upward, there is no doubt the lawyers will ask for a fee based on it," said Michael Perino, a securities litigation expert at the St . Johns University School of Law.
In other cases, the mechanistic and other relevant data are considered to determine whether the default evaluation should be modified upward or downward.
In addition, pharmacokinetic analyses indicate that because of a reduced area under the curve and enhanced clearance, the dosage of both agents needs to be modified upward in order to achieve drug levels that are comparable to those observed when the drugs are used for FDA approved indications in patients with normal kidney function and without nephrotic-range proteinuria [ 11, 12].
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"For some communication systems, we use this layer to propagate signals from point A to point B. If this ionosphere is modified by upward lightning, then it can produce some disturbances in the communications signals".
Tides can modify the upward propagation of gravity waves and their momentum deposition in the MLT region via critical layer filtering mechanisms (Fritts and Vincent 1987) and via modulation of the buoyancy frequency (Preusse et al. 2001).
This reinforces our understanding that the majority of GW are generated in the lower atmosphere, with the spectrum being modified as the waves propagate upward.
The positive charges and polarization-induced negative charges build an internal electric filed which modified the band bending from upward band bending to downward band bending, shown in Fig. 4. Because of the downward band bending, the BE increases with the increase of detection angle.
For example: a change in the utility of Actor II in Figure 5 shifts the original Pareto frontier upward into the modified Pareto frontier.
The modified method [ 17- 19] includes upward adjustments for TNBC (+4), estrogen-negative (+1), and high-grade invasive cancers (+2), and downward adjustments for human epidermal growth factor receptor 2 (HER2 -positive (-4) or estrogen-receptor positive (-1), lobular (-2), and low-grade noninvasive cancers (-2).
This is in contrast to the conventional one-dimensional upward directed seepage tests performed in a modified triaxial chamber.
Also, note that most of most extreme non-outlying downward excursions in the original signal are modified by this filter, as are many of the largest upward excursions.
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