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We have modified this figure (now Figure 7).
As requested by the referees, we have modified this figure to show a higher magnification.
To avoid confusion, we modified this figure (now Figure 1E) as discussed above to better show dose-responsiveness.
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Measurement of circulating cytokines showed that, of the cytokines TNFα, IL-6 and PAI-1, the latter was significantly increased in HFD-D mice compared with HFD-DR mice and GOS treatment significantly modified this parameter (figure 5B).
The title for Figure 4 should be modified, since this figure contains only data for beta-tubulin.
Building on this model, we propose that the hydrophobic C-terminus of 2UIM ataxin-3 modifies this process (Figure 6).
We think this was clear, however we have modified the figure legend and text to make this explicit.
We have modified the figure legends to make this clear.
We now modified the figure legend to make this clearer.
This is not obvious to me from Figure 5. Author's response: We have modified the Figure 5 to make this clear now.
We modified this statement regarding the current Figure 7, and simply made the point that the numbers we find in RPE cells are similar to those in primary cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com