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During this time, 72 patients discontinued treatment and 98 modified their regimen because of drug stock-outs.
Of the 975 patients who were on cART for at least six months, 148 (15%) discontinued or modified their regimen because of drug stock-outs.
In view of the above, Klautke et al (2007) modified their regimen, maintaining the same daily dose of capecitabine at 750 mg m−2 b.i.d.
In the follow-up interviews the same issues in applying the 'medicines-resistance' model were encountered (i.e. whether patients accepted their medicines despite concerns not being resolved, and whether they modified their regimen).
The issues in applying the 'medicines-resistance' model here concerned the extent to which patients could be considered to have accepted their medicines in the absence of resolution of their concerns (i.e. whether they did accept them), and more significantly that some patients sought medical advice because of difficulty in tolerating side effects (i.e. whether they modified their regimen).
Similar(55)
Over the course of the study, when stock-outs occurred, the proportion of patients who discontinued treatment decreased and the proportion of patients who modified their regimens increased.
However, in the previous studies, up to 50% of patients are compelled to modify their regimen in middle and low-income countries where salvage drug is still limited.
All were treatment-experienced when entering the study; three (4001, 5001 and 5007) were on therapy and changing or modifying their regimens, while the remaining two (4015 and 4030) were off ART at the study start and were initiating new regimens.
About one quarter (24.4%) of nsNSAID patients modified their drug regimen (dose changes, switching to another NSAID); 5.4% of celecoxib patients changed their dose.
In our study, 280 (28%) of 1,554 patients modified their cART regimens at least once during the follow-up (median 13 months).
Patients who discontinued and modified their cART regimens were classified as having discontinued cART, even if the modification occurred before the discontinuation.
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