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To check the myocyte dedifferentiation ex vivo, we modified the tissue culture technique to attain better viability of mouse myocytes [4], [20].
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In these studies we can modify the tissue relaxation properties of the fixed tissues to better suite the scanner hardware.
The extent of the fibrosis, or the cell density of certain tumours may modify the tissue hardness in elastography.
The next stage in developing this novel loading platform should consider modifying the tissue grips to explore the effects of different directional loading on different gene expression, and also loading different types of tissues.
Second, the model may be used to evaluate treatments that aim to modify the tissue properties using input parameters consistent with a diminished rate of calcification owing to prevention or therapy.
Senescent cells secrete numerous cytokines and other mediators that modify the tissue microenvironment.
These activities provide potent mechanisms by which senescent cells can modify the tissue microenvironment.
Paradoxically, the expression of SASP/SMS by senescent cells can also facilitate cancer progression by modifying the tissue microenvironment [ 11].
These mitogens, such as oestrogen, prolactin, and IGF-1, modify the tissue composition of the breast, resulting in variations in the mammographic image [ 6, 7].
In other words, is MSC differentiation-based repair sufficient for disease treatment, or do MSC-produced factors that modify the tissue microenvironment and lead to recovery intrinsically.
Importantly, this suggests that age-related impairments in macrophage phagocytosis could be reversible and as such could be targeted therapeutically, either directly or by modifying the tissue microenvironment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com