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In order to define the product of the TES reaction in more detail, we modified the sequence of the branch point to introduce an interrupted site for the restriction enzyme SacI across the junction.
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Since then, he and his colleagues have modified the sequences of influenza viruses to bind to a natural microRNA expressed in humans and mice, in essence developing a virus that's knocked down by the body's natural microRNA.
Similarly effective were more subtle experiments that modified the sequences of two genes, orc1 and kelch13, which have putative roles in gene silencing and emerging resistance to artemisinin, respectively.
Genome editing with the CRISPR/Cas9 system is making it possible to modify the sequence of genes linked to these disorders.
The program does not modify the sequence of the images, except to invert the sequence if the first energies are in a decreasing order.
Several studies have been carried out to modify the sequence of GLP-1 in order to prevent degradation while conserving its valuable function.
Using analytical ultracentrifugation and NMR methods, we show here that a membrane-soluble peptide, MS1, designed by modifying the sequence of the water-soluble coiled-coil GCN4-P1, exhibits a reversible monomer-dimer-trimer association in detergent micelles with a greater degree of cooperativity in C14-betaine than in dodecyl phosphocholine detergents.
As a consequence, mutations occur with high frequency, thereby modifying the sequence of the HIV-1 proteins.
Moreover, RNA editing can modify the sequence of miRNAs and the nCounter system would have not detected such editing events.
In a gene conversion process a part or the whole sequence of one of the paralogous genes is used as a template to modify the sequence of another.
There is room for improvement by modifying the sequence of miRNAs or finding other sequences common to mRNAs or proteins of interest.
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