Thus, even though selection should favor point mutations modifying the repeat sequence purity, which would decrease the propensity toward further disease-causing repeat accumulation, repeat sequence in disease-associated coding regions is more highly conserved than in nearby non-coding regions.
In Experiment 2, we modified the report and repeated the study.
ZJZ modified the manuscript and repeated some experiments.
For births in Group 1, we evaluated whether treatment of the mother modified the PR estimates by repeating the analyses in strata of births of women treated with surgery alone and births of women who received other treatment (i.e., radiotherapy, chemotherapy, or endocrine therapy).
We then assessed whether other modifiers of the pathogenic, expanded Ataxin-3 proteinrotein could also modify the CAG-repeat RNA toxicity.
Similarly, in a Drosophila model of fragile X syndrome, which is also an RNA-mediated neurodegenerative situation, upregulation of Hsc70 modifies the CGG-repeat RNA-induced effects (22).
The comparison of the habitat structure between both periods demonstrated that repeated-fire regimes modified the landscape from a homogeneous sparse forest to a contrasted heterogeneous mixture of scrubland and dense forest.
She repeated it twice, then modified the refrain.
We also compared habitat structure at the study area between 1944 and 2006 to certify that repeated-fire regimes have modified the habitat for reptiles.
Interallelic recombination can also lead to intragenic sequence exchanges that may also affect the structure of the genes by modifying the number of repeated domains, as reported for some disease resistance genes [ 52, 53].
