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The particles produced modified the release of leuprolide in vitro (dissolution in phosphate buffered saline) and in vivo (subcutaneous and pulmonary delivery in the rat).
The increment of islet CAs – induced by the administration of their precursors – significantly modified the release of insulin, suggesting that endogenous CAs can affect islet function [ 14].
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To investigate whether cholinergic ganglionic stimulus modifies the release of gonadotropin-releasing hormone (GnRH), catecholamines, and progesterone at the ovarian level.
Interestingly, formulations based on alpha cyclodextrin and soybean oil can modify the release of a lipophilic drug depending on the system formed.
The obtained alginate matrixes are able to modify the release of the entrapped IBU-L and this occurs in a pH-sensitive way that can be correlated with the swelling behaviour of the alginate-produced beads.
These effects could modify the release of gut hormones involved in the control of food intake [8].
These results indicate that after seven days, lead does not seem to modify the release of NO stimulated by acetylcholine or alter NO signaling pathways.
We therefore tested whether glucose and fatty acids could modify the release of cytokines, chemokines and growth factors by adipocytes.
Exposure of donor cells to pathophysiological conditions commonly associated with diabetes modifies the release of microRNAs and affects survival of recipient beta-cells.
The availability of a wide range of viscosity grades also allows the formulator to modify the release of drugs from HPMC matrix tablets according to therapeutic need.
This might be due to HPMC which increases the viscosity of the formulation and therefore modifies the release of drug from gel.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com