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We began the analysis by using the same set of conditions of Schmidt et al. [13] and, from this starting point, we modified the parameters according to our different conditions (different calcium indicator, different Mg-ATP concentration and different temperature) as described in detail in the Materials and Methods.
Here we modified the parameters of the underlying model for toxicity and efficacy (PSA dynamics) models for two purposes.
We modified the parameters associated with ceramidase (CDase) activity as well as the parameters corresponding to the dynamics of sphingosine kinase (SK) and ceramide kinase (CERK).
All four later developed scoring systems only marginally modified the parameters by omitting a single parameter or including vacuolization as an additional marker (Table 7).
When performing the maximization, we only modified the parameters controlling the bounds, while keeping all other parameters fixed to the maximum-likelihood values.
In contrast, treatment with A β neither affected expression of metabotropic Ca2+ signalling toolkit, nor modified the parameters of DHPG and ATP-induced Ca2+ transients in EC astrocytes.
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Then man "began to modify the parameters of the map as his needs changed," giving birth to urban maps, itineraries and nautical maps, Mr. Valerio wrote in a brief introduction to cartography for a Florentine museum.
In order to produce different daughter wavelets, modify the parameters.
The driver can modify the parameters of the controller pushing few buttons even driving the motorcycle.
This approach allows the enhancement of sensitivity without modifying the parameters in the mechanical design.
In the second step, the same iterative algorithm proposed in [18] without modifying the parameters in the natural units.
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CEO of Professional Science Editing for Scientists @ prosciediting.com