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In the present work, TNF-α modified the function of human MFs, suggesting a regulative effect of TNF-α during the wound healing.
Strikingly, however, overexpression of CD146, a previously identified niche marker, that facilitates homing and renewal of HPCs modified the function of HS5 cells, such that their in vitro effects and in vivo engraftment-facilitating capacity were similar to those observed with HS27a cells.
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Multi-target approaches are necessary to properly analyze or modify the function of a biochemical pathway or a protein family.
Cleavage of OPN by PC5/6 may modify the function of OPN in bone and/or modulate other enzymatic cleavages of OPN, leading to alterations in the bone phenotype.
The currently approved therapies for Alzheimer's disease (AD) in the US are designed to modify the function of specific neurotransmitter systems in the brain.
Curcumin has been shown to modify the function of membrane proteins by changing the lipid bilayer properties [52].
A less likely possibility is that LPA might act indirectly by modifying the function of a PPARγ coactivator.
Thus, the support cells may not be required for the chemosensation, but through CheB42a and llz, they can modify the function of the neurons they enwrap.
Phosphorylation by Cdks directs the cell cycle by modifying the function of regulators of key processes such as DNA replication and mitotic progression.
This will provide an invaluable opportunity to clone loci that modify the function of the two genes identified in our screen.
Unlike the dominant effect of germline p53 mutation on cancer risk, germline p53 polymorphisms exert more subtle effects on tumor onset or risk of cancer by modifying the function of p53.
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