Sentence examples for modified the affinity from inspiring English sources
The introduction of o-OCH3 and m-Cl into the phenylpiperazinyl moiety as well as the elongation of the linker between purine-2,6-dione core and arylpiperazine fragment modified the affinity for the tested 5-HT receptors.
These alterations have modified the affinity of GPR50 for melatonin and probably affected its interactions with the two functional melatonin receptors, MT1 and MT2, in mammals.
The existence of oxygen atoms on graphene surface could not only change the conductivity of electrode, but also modify the affinity between the electrolyte ions and the electrode surface.
For longer contact times, published data have shown that experimental biases due to progressive changes in the characteristics of the soil and the solution may drastically modify the affinity of the solutes for the soil.
Co-expression with A1R did not significantly modify the affinity of A2AR for the different ligands, but co-expression with D2R decreased the affinity of all compounds, with the exception of KW-6002.
As PK 11195 has the same effect on bacterial adhesion to polar (glass), complex (eukaryotic cells), and hydrophobic surfaces (polystyrene) and does not modify the affinity to solvents of the bacteria, global variations of surface polarity can be excluded.
On the other hand, co-transfection with D2R significantly reduced the affinity of A2AR for MSX-2, SCH-420814, SCH-58261 and ZM-241385, from two to about nine times, and did not significantly modify the affinity of A2AR for KW-6002 (Table 3).
In contrast, mimicking phosphorylation at Ser396 and Ser404 (S396did404D) did not modify the affinity of 3-repeat Tau isoforms for Fyn/SH3.
According to the informatics software, this polymorphism had a functional effect in modifying the affinity of the sequence by the MZF1 transcription factor.
According to the informatics software, this polymorphism had a functional effect modifying the affinity of the sequence by the MZF1 transcription factor.
Removal of the α-tubulin tail did not further modify the affinity of the motor domain for microtubules that also lacked the β-tubulin tail.
