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These alterations could have modified the activity of receptors in cell membranes, thus altering the activation of intracellular pathways and downstream regulatory proteins, such as those related to the IGF-1/PI3-K/Akt/mTOR pathway, which are compartmentalized and activated through their translocation to the plasma membrane [ 52].
To expand its engagement and learning potential, we modified the activity for small groups and incorporated several active learning elements.
We also demonstrated that BMP-6-induced downregulation of miR-21 modified the activity of PDCD4 3′UTR and inhibited MDA-MB-231 cell invasion.
Therefore, we aimed to explore whether Sema3E modified the activity of ADF/Cofilin, a well-described F-Actin-depolymerizing factor under the control of LIM kinases (Fig. 5h, Supplementary Fig. 10).
Each peptide modified the activity generated by some of the neurons identified in a locus of the ventral ventricular ganglionated plexus of each animal.
Inoculation of pig manure with worm-worked substrates also modified the activity patterns of the four enzymes analyzed.
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Another participant stated " I modified the activities I do so it's less demanding on the ankle but still enjoyable' (p2).
Moreover, green tea catechins have the ability to modify the activity of multiple intracellular molecular targets, including mitogen-activated protein kinase (MAPK), protein kinase C, and PI3K/Akt pathways.
They made the surprising discovery that the virus was only the indirect cause; it triggered the cancer by modifying the activity of a gene already within the cells.
Simple measures such as icing, using nonsteroidal anti-inflammatory drugs (NSAIDs), and reducing or modifying the activity that aggravates the symptoms can be instituted early in treatment.
Using this knowledge we have recently designed targeted optogenetic approaches to detect seizures at their onset, and then in real time disrupt them by instantly modifying the activity of key elements in the epileptic circuit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com