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The relative stoichiometry of the modified state of the population of substrate molecules is a function of the PTM's "writers" and "erasers" [ 27].
Thus, each species in the perturbation-response model can represent a molecule, a different modified state of a molecule (e.g. ubiquitinated state) or a molecular process such as diffusion, endocytosis, etc.
The antibody has to be able to discriminate between the unmodified and the modified state of the targeted amino acid residue, as well as between different forms of modifications (e.g. acetylations of different lysine residues, mono-, di- and trimethylation of lysine residues, or symmetric and asymmetric methylation of arginine residues).
'We all go through life in a modified state of high school,' says Neil LaBute, director of In the Company of Men and Nurse Betty.
In El Salvador, they said, the government lagged in declaring a modified state of emergency, apparently out of fear that it would drive up interest rates on foreign loans.
Thus, mathematical models face enormous obstacles in trying to account for all of the possible signaling crosstalk and to account for the abundance (and potential modified state) of each of the players in all of their potential subcellular locations.
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According to the company's history, Hughes Aircraft was designed to modify state-of-the-art military aircraft for racing.
By comparing heavy/light ratios from a mutant and wild-type pair, the impact of the modified state on H3K79 and H3K56 modifications could be determined.
Non-competitive NMDAr antagonist-induced persistent γ hyperactivity was recorded under diverse brain states: in conscious freely moving rats and in deeply modified states of consciousness.
This experimental model enabled us to follow the effectiveness of O2 delivery through ILA during different, acutely modified states of impaired pulmonary gas exchange as reflected by the broad range of pulmonary venous admixture detected.
The alternating tubulin array in T. brucei and the distinct, monotypic arrays in L. major are representative of their respective genera and mutually exclusive, i.e., they are not modified states of a common ancestral character.
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Justyna Jupowicz-Kozak
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