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The modified scaffold showed predominant biofunctionalities and promise for bone tissue engineering in alveolar bone resorption.
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The modified scaffolds showed a beta-sheet structure.
The modified scaffolds showed high tendency to induce cell adhesion.
The modified scaffolds showed swelling ratios, weight losses and mechanical properties similar to those of unmodified scaffolds.
The modified porous scaffolds showed a layer of collagen and mineralized collagen fibrils on the surface.
(A) Photograph of the collagen (CL -chondroitin sulfate modified sCL -chondroitin
Extracellular/acellular matrix has been attracted much research interests for its unique biological characteristics, and ACM modified neural scaffolds shows the remarkable role of promoting peripheral nerve regeneration.
Despite lower initial cell adhesion than untreated, all modified scaffolds promoted proliferation of human mesenchymal stem cells (hMSCs) and showed >95% cell viability at all time points.
The results showed early formation of focal adhesion (FA) complex on R-peptide modified scaffolds at 30 min after cell seeding.
Those modified scaffolds are then ordered and oriented.
Additionally, it was determined that modified scaffolds have proangiogenic activity.
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