Sentence examples for modified rat models from inspiring English sources

In the three years since rat embryonic stem (ES) cells were first reported the anticipated proliferation of genetically modified rat models from this new resource has not been realised.

The development of genetically modified rat models provides a valuable means of understanding the cognitive dysfunction associated with the loss of FMRP, as well as providing cross-species validation of cellular dysfunction that will strengthen the relevance of genetic models of FXS to the human disorder.

There are many situations where a genetically modified rat is a preferred model.

However, the use of rat models in mechanistic studies has been limited due to lack of genetically modified rat strains.

However, use of this rat model for mechanistic and chemopreventive studies is limited due to lack of genetically modified rat strains.

None of these treatments significantly modified rat temperature.

Thus in spite of a need for genetically modified rats as an important alternative to mice, developing such models has simply been beyond the reach of most investigators.

We therefore implemented and modified an experimental rat model, in which CC531 tumor cells were implanted into syngeneic WAG/Rij rats [ 11].

Firstly, we used a dose that has previously been shown to clearly modify disease processes in several rat models (Boettger et al. 2008, Zanella et al. 2008, Hsu and Chang 2010).

We cannot rule out the possibility that agonists produced by the PVAT in FRD rats modified the vascular smooth muscle cells-IP3 receptor properties, as it occurred in rat models of type 1 diabetes [ 50].

To better evaluate the efficacy of 5-LO Xinhibitors for pharmacological intervention, a rat model was modified to test the in vivo efficacy of 5-LO Xinhibitors.