Most reported proteomic analyses of posttranslationally modified proteins involve global profiling of phosphorylation dynamics and other protein modifications by shotgun proteomics, with quantitation by metabolic labeling (e.g., SILAC) or isotope tagging (e.g., iTRAQ).
The elusive enzyme that modifies proteins involved in building bone and teeth has now been identified.
Second, we envisioned that a C1_5 protein might have a second domain with enzyme activity that might be activated by DAG to post-translationally modify proteins involved in endocytosis thereby enhancing Tf uptake.
Although SPY, the negative regulator of the gibberellic acid (GA) signaling pathway, has been identified in Arabidopsis as a homologue of O-GlcNAc transferase, O-GlcNAc-modified proteins involved in GA signal transduction have not been determined.
Therefore, the present study investigates the relative levels of posttranslationally-modified proteins involved in signal transduction, transcription, and translation processes using ELISA in lemur tissues comparing torpor and aroused states.
Some toxins are enzymes that modify specific proteins involved in protein synthesis or in control of host cell metabolism; examples include the diphtheria, cholera, and pertussis toxins.
Human tankyrases post-translationally modify multiple proteins involved in processes including maintenance of telomere length, sister telomere association, and trafficking of glut4-containing vesicles.
Brief PAD activation in response to Ca2 + oscillations may therefore be required to modify target proteins involved in some of these processes, but not sufficient for extensive citrullination leading to cell death.
Interestingly, partially modified proteins tend to occur on proteins involved in transport.
