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Side effects were regularly monitored and therapy was modified or stopped according to standard guidelines.

The investigators and independent researchers will assess the progress of the clinical trial and severe adverse events and determine whether they are acceptable and whether it will be necessary for the trial to be modified or stopped.

Such markers would enable treatment to be administered most effectively along with assessment of positive response to therapy such that the treatment can be modified or stopped in a timely manner to best manage adverse side effects.

All the hospitalized patients were administered empiric broad-spectrum antibiotics (ceftriaxone or ciprofloxacin) after initial laboratory test and physical examination, and the regimen was modified or stopped according to the results of the cultures or the infection [ 7].

The trial has an independent Safety and Data Monitoring Committee to safeguard the patients' interests and to formally evaluate from time to time on a regular basis whether, for any reason, they would recommend that the study should be modified or stopped.

No single biomarker of bloodstream infections may be ideal, but many are helpful in terms of identifying bacterial infections in critically ill patients who need close monitoring so that the antibiotic therapy may be modified or stopped as soon as possible.

Similar(54)

Expectations of those considering knee OA an occasional problem are mainly symptom relief, whereas expectations of those considering knee OA a chronic problem are to dispose of a treatment being able to modify or stop OA evolution.

It recommends to the sponsor whether to continue, modify, or stop the trial based on their assessment of the data.

The committee assesses the progress of the trial, and the safety data and advises whether to continue, modify or stop the trial every 3 months.

Following each interim analysis, the Data Monitoring Committee made recommendations to continue, modify, or stop the trial, based on interim analysis results (stopping criteria at n1 = 60, boundary P-value = 0.00015; n2 = 40, boundary P-value = 0.00258; n3 = 100, boundary P-value = 0.02396).

DMSB: A Data Safety Monitoring Board (DSMB) will be appointed to review the study progress, safety data, critical efficacy outcomes, at regular intervals and recommend to the sponsor whether to continue, modify, or stop the trial.

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