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Originally, the prince wanted a strictly Classical design, and plans for such a design were executed, in Chester by architect Thomas Harrison and modified, on site, by Odessa architect Francesco Boffo.
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While the guns once fired live ammunition, they have been modified on-site so that they now shoot blanks, if they shoot at all.
The main disadvantage with CAD is that the finished drawings may be more useful from the manufacturer's point of view since they are difficult to update or modify on site without access to the original drawing data files.
Based on a proteome-wide PTM analysis it was suggested that, on average, all human proteins are modified on at least three sites.
As an example, human p53 has been reported to be potentially post-translationally modified on at least 18 sites [ 23] including phosphorylation, acetylation and sumoylation, with implications for DNA binding, stability, oligomerization, nuclear import/export and ubiquitination [ 24].
Cell binding sites are either modified on surface after scaffold formation, or naturally exist or supplemented into the scaffold during fabrication.
This article was modified on 20 August 2013.
This article was modified on 28 July 2013.
While the CID spectrum did not fully define the site of modification, the ETD spectrum contained the critical fragment ions to unambiguously define S395 as the only O-GlcNAc modified site on TAB1.
* (This airfoil caused severe stability problems; the Wrights modified the camber on-site).
An electro-positive groove formed by tandem ARM repeats serves as a binding site for the JMD and CBD, which can be postranslationally modified at multiple sites; depending on the site, the interaction between cadherin and catenins is either strengthened or weakened (Dupre-Crochet et al., 2007).
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