Sentence examples for modified mouse line from inspiring English sources
To evaluate the physiological function(s) of PDZ-RhoGEF, we generated a genetically modified mouse line bearing a conditionally targeted PDZ-RhoGEF allele, Arhgef11.
We have therefore now performed an experiment similar to that of Malanchi et al (2008), using a genetically modified mouse line that enabled us to study the effect of a tamoxifen-induced, hepatocyte-specific knockout of Ctnnb1 during chemical hepatocarcinogenesis.
In the future, the pneumonectomy mouse model combined with genetically modified mouse lines, lineage tracing approaches, and single-cell transcriptomic analyses will be powerful tools to shed new lights on the regenerative aspects associated with de novo alveologenesis.
A number of genetically modified mouse lines with gain- and loss-of-function mutations in Pdgf and Pdgf receptor genes have been created in order to understand PDGFs physiological functions.
Two genetically modified mouse lines were used; the diminuendo line and the Ptprq-CAT-KO line.
To date, several genetically modified mouse lines have provided clues on genes and pathways involved in the development of ADHD-related behaviors, and these studies have been reviewed recently (Leo & Gainetdinov, 2013).
To investigate whether the presence of this extensive cytoplasmic membrane system was directly responsible for promoting the reorganization of the Golgi apparatus in these differentiated cells, we exploited genetically modified mouse lines with the parietal cells lacking specialized TVE.
Furthermore, the identification of genetically modified mouse lines that model aspects of human developmental abnormalities offers the possibility of investigating the complex interactions of environmental factors that can affect disease prevalence and severity.
The Mouse Genetics Project (MGP) at the Wellcome Trust Sanger Institute aims to generate and phenotype over 800 genetically modified mouse lines over the next 5 years to gain a better understanding of mammalian gene function and provide an invaluable resource to the scientific community for follow-up studies.
This will not only help to extend our understanding of normal tissue and organ development but, by applying the same approach to embryos from genetically modified mouse lines, such imaging studies could also transform our knowledge of gene function in embryogenesis and the aetiology of developmental disorders.
A genetically modified mouse pro-B cell line carrying this chimera showed selective expansion in the presence of fluorescein-conjugated BSA (BSA-FL) as a growth inducer.
