Sentence examples for modified mouse embryonic from inspiring English sources

By using genetically modified mouse embryonic fibroblasts, caspase-9 was proven to be indispensable for triggering LMP, but the exact mode of action remains elusive.

The ease of accurately measuring IL-12 p40 secreted from transfected ES cells in culture prompted us to use the IL-12 p40 to develop a high-throughput screening strategy to identify successfully modified mouse embryonic stem (ES) cells.

This chapter aims to (i) provide a current overview of selected mouse databases and online information resources of relevance to transgenic and gene targeting research and (ii) highlight and promote the use of standardized nomenclature for naming transgenes, targeted and gene trap mutations, and genetically modified mouse strains and embryonic stem cell lines.

A conventional and useful approach for understanding gene function has involved producing genetically modified mice from embryonic stem cells (ESCs) that contain genetic changes since the successful derivation of mouse ESCs from blastocysts (D; Martin, 1981; Thomas and Capecchi, 1987).

Genetically modified mouse strains derived from embryonic stem (ES) cells have become essential tools for functional genomics and biomedical research.

A number of initiatives, both publicly and privately funded, have now been developed to create repositories of gene-targeting vectors, genetically modified mouse strains and predeveloped embryonic stem cells carrying specific mutations.

The generation of genetically modified mouse strains by homologous recombination in embryonic stem (ES) cells is a major research tool in diverse fields of biology.

However, heterologous skin equivalent models have the unique advantage, that genetically modified mouse cells can be exploited such as embryonic fibroblasts from knock-out or transgenic mice.

In conventional methods for the generation of genetically modified mice, gene-targeted embryonic stem (ES) cells are injected into blastocyst-stage embryos or are aggregated with morula-stage embryos, which are then transferred to the uterus of a surrogate mother.

Transgenic, knockout and other genetically modified mice are typically made using embryonic stem cells, which are then implanted in an early embryo [7], [8].

Mouse embryonic stem cells are widely used to create genetically modified mice.