Sentence examples for modified mice in from inspiring English sources
In experiments with genetically modified mice in 2001 and 2007, Demetriou and colleagues demonstrated that disrupting sugar levels in T-cells launched them into a hyperactive state and led to a spontaneous MS-like autoimmune disease.
Yet over the past decade they have come to accept not only that animal experimentation can often be justified but also the increased use of genetically modified mice in carrying out such tests.
The experiments used genetically modified mice in which the gene that encodes REST was prematurely switched off in neural stem cells.
This will be facilitated by the availability of a range of genetically modified mice in which HA-responsive components of well-established cellular pathways have been modified.
Genetically modified mice in which Mcl-1 can be deleted in an inducible fashion in hematopoietic stem cells rapidly lost these cells after gene-deletion [ 12].
It seems likely that, within a few years, the use of genome editing to generate human cell-based disease models will become a standard, routine approach in the laboratory that could rival the use of genetically modified mice in popularity.
These outcome measures were substantially reduced, however, in Cyp2e1− null mice (genetically modified mouse in which Cyp2e1 gene is inactive) compared with wild-type control mice, suggesting that CYP2E1 is essential for development of gut leakiness.
In light of our previous work we asked whether WNK regulated blood pressure via SPAK and generated a genetically modified mouse in which WNK can no longer switch SPAK on.
The researchers used a type of genetically modified mouse in which it is possible to identify or 'tag' the activity of a population of hippocampal neurons at multiple time points.
These data permit the design of novel tests assessing behavioural changes, memory and learning in normal and genetically modified mice, both in the laboratory and in naturalistic settings.
In this study, we found that LIMK2 expression is reduced in intestinal tumours from genetically modified mice, and in human CRC cell lines and tumours.
