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Fate tracking of alveolar epithelial cells in genetically modified mice has demonstrated that mesenchymal cells arising during the progression of pulmonary fibrosis can originate from epithelial cells [61, 69, 70].
Increased lifespan in genetically modified mice has been linked to either a reduction in free radical production or alterations in the insulin signaling pathway [25].
Data obtained from various screens on different cancer models (including studies with genetically modified mice) has been compiled into the Retroviral Tagged Cancer Gene Database (RTCGD, http://rtcgd.ncifcrf.gov) [19] which also provides annotations for the UCSC genome browser [20].
Analysis of genetically modified mice has revealed multiple functions for Hh signalling during thymocyte development 6.
The development of genetically modified mice has greatly facilitated the study of LTP-like processes in memory.
Recent work with genetically modified mice has, however, demonstrated a potential psychological process that controls the expression of spatial information that results in alternation behavior.
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Despite our growing knowledge of the way that cancer develops in human cells, mutations can't be studied effectively in a petri dish, and, since the late nineteen-eighties, genetically modified mice have served as the standard proxy.
Since their introduction, genetically modified mice have become more and more important to examine molecular mechanisms involved in vascular growth.
At first glance, the modified mice had apparently normal eyes: The lens cells had lost their nuclei and other internal structures.
Compared to normal mice, the modified mice had very low levels of cholesterol both in the blood and the liver; they also had about 20% to 60% less total sterols.
Studies using genetically modified mice have proposed a large number of candidate 'pain genes'[6].
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