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CD36 facilitates ox-LDL uptake by binding the modified lipids and internalizing the particles [4].
Further, other assays will be required to identify and quantify the modified lipids and proteins [9], [45], [46] that are widely believed to accompany ARM progression.
Many immunomodulatory properties have been assigned to native and modified lipids and the immunological properties of native and oxidized lipoproteins are influenced by their content in anti- and pro-inflammatory lipids [12] [14].
Oxidatively modified lipids and proteins are present both in plasma as well as atherosclerotic lesions.
SRAI is primarily implicated in homeostatic functions such as the uptake of modified lipids and proteins, in addition to having a role in pathogen clearance [ 12, 14].
Similarly, vascular complications of atherosclerosis are mediated by lectin-like oxidized low-density lipoprotein-1 (LOX-1) receptors that bind oxidatively modified lipids and stimulate downstream signaling involving nuclear factor kappa B (NFκ B) (Navarra et al. 2009).
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Furthermore, we measured oxidized LDL (oxLDL); OxLDL represents a mixture of oxidatively modified LDL particles, containing oxidatively modified lipid and apoB protein components.
We postulate that oxidatively modified lipid and protein mediators produced within the lung and heart might promote vascular pathology through LOX-1 and/or RAGE signaling in a pollutant-specific manner.
Rab5 has been known to recruit phosphatidylinositol kinases that modify lipids and create membrane domains for recruitment of effector proteins [29].
Under oxidative stress, cells may produce an excess of ROS/RNS which react with and modify lipids and proteins in the cell [ 116].
Thus, this family of GNAT fold enzymes has evolved to function in conjunction with tRNAs, and regular or specific paralogous AAtRSs, charging the cognate amino acids in synthesis of amino acid derived antibiotics or in modifying lipids and proteins.
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