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Transplantation of genetically modified keratinocytes has been shown to accelerate wound healing.
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Neo- epidermis reconstructed in vitro, either in cell culture inserts or on dermal substrates, from such modified keratinocytes also produced the monoclonal antibody.
A model of skin consisting of co-cultured fibroblasts and keratinocytes has been suggested [106].
However, the emergence of BE from squamous keratinocytes has not yet been demonstrated.
The expression of these non-classical HLA alleles by keratinocytes has not previously been recognised.
However, basonuclin's role in keratinocytes has not been demonstrated in vivo.
Recently, the role of neutrophil defensin 1 in the integrity of keratinocytes has been demonstrated and in low concentrations of this molecule, keratinocyte proliferation is enhanced [ 57].
In general, REDD1 role in skin and keratinocytes has not been studied; a single report suggests increased keratinocyte differentiation in vitro due to REDD1 (Ellisen et al, 2002).
Intermediate filaments such as vimentin in fibroblasts and CK10 in keratinocytes have been found to be modified by AGEs., Cytoskeletal proteins are important in providing stability of the cytoskeleton and are crucially involved in numerous cellular functions such as migration and cellular division.
Keratinocytes have the ability to adhere to extracellular matrix rapidly.
Within this study primary rat keratinocytes have been transfected with anti-MHC I-IB.
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