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CI, confidence interval; E1, estrone; E1S, estrone sulfate; E2, estradiol; max; min; mITT, modified intent to treat.
HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; mITT = modified intent to treat.
Modified intent to treat analyses, including all participants who attended the first session, assessed effects across CBT-PI, CBT-P, and EOC groups.
All efficacy analyses were performed on the modified intent to treat (mITT) population (all randomised patients who had taken ⩾1 dose of study medication).
PROs reported here are prospective secondary endpoints from patients forming the modified intent to treat (mITT) population enrolled in the two treatment groups of the APPEAL study.
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Abbreviations: mITT, modified intent-to-treat; nVNS, non-invasive vagus nerve stimulation; SoC, standard of care.
Abbreviations: CI, confidence interval; mITT, modified intent-to-treat; nVNS, non-invasive vagus nerve stimulation; SoC, standard of care.
The modified intent-to-treat analysis of percent change in daily diary pain intensity scores showed no significant differences among the 3 drugs (ANOVA P =.120).
The primary measures were comparison of the proportions of subjects (modified intent-to-treat population [mITT]) in the lasmiditan 200 mg and placebo groups who, at 2 hours post first dose, were headache pain free and MBS free.
mITT, modified intent-to-treat.
mITT, modified intent-to-treat; SD, standard deviation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com