Finally, the expression of proteins that regulate key synaptic functions is modified in the same brain regions.
Later on, Kundakovic et al. (2009) found that the same DNMT inhibitors inhibited the DNMTs, DNMT1, DNMT3A, and DNMT3B, leading to decreased DNA methylation and the reorganization of chromatin surrounding the regulatory regions of the RELN and GAD1 genes, which have been found to be epigenetically modified in postmortem brains of patients with schizophrenia.
Our finding that several proteins whose expression profiles are known to reflect the vulnerability status of axons and synapses have modified expression levels in the brains of two NCL mouse models provides further evidence in support of synaptic and axonal vulnerability in these disorders.
In this study, we first show that BACE1 is highly modified with bisecting GlcNAc in the brains of AD patients.
Regarding this, the observation that neither astemizole nor calcitriol modified the expression of EAG1 in the brains of the treated mice, as they did in breast cancer, was of particular importance since normal brain cells express EAG1.
Brain natriuretic peptide (BNP) was, however, not significantly modified in the rats (not shown).
Detergent-insoluble parkin covalently modified by an oxidation product of dopamine was found in dopamine-treated cultured cells as well as in the brains of PD patients [15].
In congestive heart failure (CHF), this distribution is modified in favour of the coronary, brain and kidney circulations, depending on the main regulatory mechanisms of the vasomotor system, including the sympathetic nervous system, the vascular endothelium and the local non-endothelial mechanisms.
For example, Falk et al. [ 31] identified a number of potentially derived features in an endocast of H. floresiensis, and comparative analyses of the brain anatomies of these species might show whether similar structures are modified in independent episodes of brain mass reduction.
Because 5hmC is most abundant in brain tissue, it has become a priority to understand the function of this modified base in the brain.
