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If a drug is prescribed in a manner outside the description given in the SmPC (or 'label'), then this use is known as off-label (used in an indication, dosage or patient group not specified in the label), unlicensed (modified in form or strength in a way that has not been assessed or approved, such as splitting a vial into syringes) or potentially both off-label and unlicensed.
To validate the observation, the classic model on first crack strength is modified in this study by adopting a refined fiber bridging relation and employing iterated crack profile.
To this end, it is important to say that the electrostatic interactions are modified in a physiological environment, where ionic strength acts to modify the complex overcharging.
Finally, this task might be too physically demanding for mice, and therefore should be modified in order to accommodate mouse size and physical strength.
Using accelerators and activators, the vulcanization reaction can be modified in various desirable ways, and sulfur interlinking also yields products of higher strength.
Dressed in traditional maroon robes modified in the style of karate uniforms, the nuns' smiling faces conceal an incredible energy and strength.
Others were modified in intriguing ways.
It was last modified in 2012.
This was further modified in WWE SmackDown!
The boundaries were again modified in 1908.
Antiretroviral therapy was modified in eight patients.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com