Sentence examples for modified histone in from inspiring English sources

In this first genome-wide analysis of a modified histone in a woody tissue, we optimized a ChIP-seq procedure suitable for field-collected samples.

To the best of our knowledge, this is the first genome-wide study of the role of a modified histone in developing wood.

ChIP-seq combined with a nano-ChIP-seq protocol allowed us to produce high-quality profiles of a modified histone in developing secondary xylem tissue, here in mature Eucalyptus trees, closely following standards recommended by the ENCODE Consortium [ 48].

For each methylation type, the difference in frequency of occurrence of nucleosomes with each type of modified histone in these regions between the peak and broad promoters was significant (P < 1.0 × 10-10 for H3K4me1 and 2, and P < 1.0 × 10-50 for H3K4me3; chi-squared test).

Using differences in peak calls alone, as is done in typical Venn diagrams comparing peaks called for a transcription factor or modified histone in two or more conditions [ 27- 29], can dramatically over-state the differences between ChIP-seq profiles, and result in thousands of erroneous calls of differentially bound regions.

Except for information on a handful of genes [19], [20], virtually nothing is known on the genomic distribution of post-translationally modified histones in preimplantation embryos.

The binding patterns of modified histones, in particular H3K9me3 and H3K36me3, are not narrow but instead can spread over large regions and exhibit very jagged enrichment profiles.

This procedure shows the presence of modified histones in individual injected nuclei.

Currently, access to specifically modified histones in vivo is mainly limited to genetic strategies.

It is also well suited for detecting patterns of modified histones in a genome-wide manner [ 78].

However, the expression and prognostic significance of modified histones in breast cancer has not been previously explored.