Sentence examples for modified genetic background from inspiring English sources

In this modified genetic background, that is, without an active sxtI homolog, and therefore no carbamoylated saxitoxins, the lack of a decarbamoylating enzyme, SxtL, seems evolutionally logical.

Most studies of particular enzymes are performed in a modified genetic background specifically developed to facilitate mutagenesis, protein purification, deletion of extraneous genes for functions that interfere with measurement, etc., and in these cases, it is of interest to generate auxotrophic strains by deletion of a particular gene.

Potential sources of variation include different risks associated with different mutations, modifying genetic background and environmental or lifestyle factors.

Similarly, the contribution of sex chromosomes to EAE and experimental myocarditis susceptibility might be modified by genetic background [ 79].

Alternatively, it may be that the penetrance of the mutation is modified by genetic background or environmental factors.

Many previously reported 'private' causal variants have now been found to be present with low allele frequencies in apparently healthy human populations and are thus unlikely to be truly causal or at least are modified by genetic background effects.

Indeed, if the fixation of mutations that confer resistance to atrazine modify the genetic background such that subsequent mutations conferring resistance to carbetamide have a higher selection coefficient (positive epistasis), then generalists are more likely to evolve in a cyclic environment compared to a homogeneous one.

These studies found significant interactions among IDH, MEN, and G6PD [measured to represent both NADP-reducing PPP enzymes as per Wilton et al. (1982)], although the magnitude and directionality of the change differed depending on which gene was modified and the genetic background.

Moreover, the phenotypes were clearly modified by the genetic background of the mice.

Despite several chromosome regions that were stable, effect sizes were modified as the genetic background varied.

Moreover, distinct measures of proteotoxicity were independently modified by the genetic background.