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The dchip processed data were also used for genotype comparisons using the modified fold change method, where the fold change threshold was 1.2, using the lower bound of the 90% confidence interval for fold change.
Gál, Z. et al. Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter.
Alternatively, we cannot rule out the possibility that the presence of the HCV domain III might modify the folding of the GBV-B domain II in this chimeric construct, thereby potentially affecting important GBV-B replication signals.
(A ) Heatmap of the expression values of genes modified >1.5-fold in the presence of E2.
The wings and stabilators are modified for folding to maximise the number of aircraft the carrier can accommodate and to allow ease of movement on deck.
This is a modified version of fold enrichment score from DAVID software [ 68].
In contrast to the unmodified tRNA, the time courses for folding of modified tRNA at all Mg2+ concentrations showed no slow phases within the 10 20 s time limit of manual pipetting.
Molecular modeling studies using the published coordinates of human 17βHSD1 suggest that these inhibitors occupy the modified Rossmann fold at the nicotinamide end of the dinucleotide-binding site, extending towards the substrate site.
Members of the SDR family bind NAD(P)(H) in a motif that is a modified Rossmann fold.
Newly synthesized proteins are modified and folded in the ER.
Then, a modified version of the usual RNA folding methods (like Mfold[ 15] and RNAfold[ 16]) is applied to cope with the linker symbol to predict the correct energies.
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