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This observation suggests that modified expression of a relatively small subset of ROS-associated or -induced genes may suffice for a degree of tolerance to ROS.
Firstly, FGFR3 activating mutations affect input signals (modified expression of other growth factors and membrane bound receptors, biochemical properties of the ECM).
The RT-qPCR analysis detected two clusters (Dio3, Rtl1, Dlk1 on chromosome 12 and Slc22a1, Slc22a2, Slc22a3 on chromosome 17) displaying modified expression of genes involved in regulation of homeostasis.
This enhanced disease resistance was accompanied by increased accumulation of endogenous salicylic acid (SA) and suppressed accumulation of endogenous jasmonic acid (JA) as well as modified expression of a subset of defense-responsive genes functioning both upstream and downstream of SA and JA.
In turn, modified expression of several of these molecules, including CaMK [2], AMPK [3], [4], PGC1α[5], [6] and β[7], and PPARδ [8], directly alters metabolic outcomes in mice including adiposity, glucose tolerance, oxidative capacity, and endurance (or resistance to fatigue).
Such ovaries showed modified expression of various carpel-related genes.
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In degenerated disc tissue, modified expressions of MMPs, ADAMTSs, and TIMPs have also been detected [ 12- 19].
Functional delivery of oligonucleotides to epidermis in order to edit or modify expression of mutant genes.
Signal transduction leads to modifying expression of defense-related genes and defense mechanisms against BPH, including sieve tube sealing, production of secondary metabolites, and induction of proteinase inhibitor.
Previous studies have shown that combination therapy modifies expression of hundreds of genes in vitro and in vivo.
However, GGTI-298 alone (10 µM) did not significantly modify expression of MHC-I and in particular HLA-A0201 (Figures 3A and 3B).
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