Sentence examples for modified expression levels from inspiring English sources

We have used a conditional null mutant mouse model in a proteomics approach to identify proteins with modified expression levels after 4 Gy ionizing irradiation in the absence of nibrin in vivo.

Perhaps the most exciting finding of the present study is that modified expression levels of two distinct proteins (VDAC1 and Pttg1) robustly occur during the pre/early-symptomatic stages of disease progression in both mouse models of NCL examined.

The data showing that several of these synaptic proteins have modified expression levels pre/early-symptomatically in NCL mice suggests that synaptic changes at the molecular level are instigated in advance of any overt neuropathological changes.

The finding that several cell-cycle-related proteins have modified expression levels provides evidence that the cell-cycle status of terminally differentiated neurons and/or their supporting cells is altered in the NCLs.

Both VDAC1 and Pttg1 showed significantly modified expression levels in hind-limb muscle preparations (including quadriceps, hamstrings, gastrocnemius and soleus) from Ppt1 −/− mice compared with wild-type littermate controls (Fig.  8B and C).

Our finding that several proteins whose expression profiles are known to reflect the vulnerability status of axons and synapses have modified expression levels in the brains of two NCL mouse models provides further evidence in support of synaptic and axonal vulnerability in these disorders.

In other words, it contains all the time intervals during which the (modified) expression level is below t.

Of the >14,500 unique tags identified in both libraries, 224 had a modified expression level; they are known to participate in inflammation, ion transport, signal transduction, oxidative stress, apoptosis, metabolism, and catabolism.

Acute down regulation of endogenous APP expression did not modify expression levels of APLP1 and APLP2 (Fig 1L), but induced a significant increase in HMGCR mRNA levels (Fig 1M), cholesterol biosynthesis (Fig 1N) and SREBP1 expression (Fig 1O).

We hypothesized that there would be an association between changes in ambient PM2.5 levels and modified expression of circulating cell-surface phenotypes that mediate innate immune activity, and that this effect would be more pronounced in individuals who were obese, had elevated HbA1c, or were GSTM1 null.

In our experiments and those of others, all plants with modified AOX expression levels that have been evaluated have been challenged with only one virus.