7 8 Comorbidity potentially modifies effectiveness of therapies and the clinical course of a myocardial infarction.
In their conclusions it is pointed out that there is scarce evidence on which strategies are the most effective in each situation, for which reason the authors consider necessary the development and validation of theoretical models of behaviour change, as well as investigation of the efficiency of the strategies given the presence of different obstacles and factors which may modify effectiveness.
In a subgroup analysis of the intervention group, baseline AHI significantly modified the effectiveness of treatment, with a greater improvement in AHI in patients with severe obstructive sleep apnoea (AHI >30) at baseline compared with those with moderate (AHI 15-30) sleep apnoea (AHI −38 v −12, P<0.001), despite similar weight loss (−19.2 v −18.2 kg, P=0.55).
Although the study was not powered to do so, an attempt was made to stratify all analyses by high (>10% initial prevalence) and low (≤ 10% initial prevalence) malaria transmission to assess whether malaria transmission modified the effectiveness of the MTAT intervention.
Figure 2 shows the impact on cost-effectiveness of modifying vaccine effectiveness and price.
The objective of this article is to present the design of a blind randomised clinical trial that examines the long-term symptom-modifying and disease-modifying effectiveness of GS in patients with hip OA.
However, it is possible that the quality of standard care may modify the effectiveness of self-monitoring, and in turn, influence its cost-effectiveness.
It is well-documented that the context into which interventions are implemented may modify their effectiveness (Victora et al. 2004, 2005), but there is limited knowledge on the effectiveness of CMAM when scaled-up and integrated into an existing government health system that is currently occurring in many countries.
To generate a cost-effectiveness acceptability curve, we conducted a probabilistic sensitivity analysis using Monte Carlo simulation methods modifying the effectiveness of the intervention to reduce HIV incidence using a triangular probability distribution [27] with a range between 0% and 60% with 40% effectiveness as best estimate.
Such land bridges allowed migration of animals and plants during the lowstands, but in high latitudes the effects of cold climate and direct blockage by glaciers could modify their effectiveness.
