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Most antisense RNAs are synthetically modified derivatives of RNA or DNA with potential therapeutic value.
The current continuous-flow pumps are modified derivatives of one that Dr. Richard K. Wampler developed in the 1980s.
The Nod factors are diversely modified derivatives of lipochitooligosaccharides (LCOs) and are also called Nod-LCOs.
Several chemically modified derivatives of HA have been developed to circumvent the disadvantages of HA.
For these reasons, there has been a significant commercial focus on the development of products either from HA or from chemically modified derivatives of HA.
Chemically modified derivatives of superoxide dismutase (SOD), i.e., cationized (Cat-SOD) and mannosylated SOD (Man-SOD), were designed to improve an ability of SOD to suppress reactive oxygen species (ROS -mediated injuROS -mediatedeolar epinjuryum.
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A mutagenized and genetically modified derivative of Salmonella enterica serovar Typhimurium 14028S, VNP20009 (ATCC 202165), is attenuated in host virulence and accumulates preferentially in tumors.
To improve the half-life and tissue targeting of SOD to suppress reactive oxygen species (ROS -mediated injuROS -mediatedy modinjuryderivative of superoxide dismutase (SOD) with heparin, anionized SOD (Hep-SOD), was designed.
The present study was designed to investigate whether three sodium hyaluronic acid (HyA) medical products, Artz®, Suvenyl® and a chemically modified derivative of sodium HyA Synvisc®, can be used as suitable vehicles for an osteoconductive octacalcium phosphate (OCP).
Furthermore, owing to the poor activity of B-13 on lysosoamal acid ceramidase in living cells, LCL-464 a modified derivative of B-13 containing a basic ω-amino group at the fatty acid was reported to have higher potency towards lysosomal acid ceramidase in living cells.
In the present work, we engineered PTX-loaded polyelectrolyte films and microcapsules by pre-complexing PTX with chemically modified derivative of hyaluronic acid (alkylamino hydrazide) containing hydrophobic nanocavities, and subsequent assembly with either poly l-lysine) (poly l-lysinernized chitosan (QCHI) as PLLycatiors.
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