The most frequent reason for modifying cART was toxicity to cART (56.2%), i.e. peripheral polyneuropathy in 26.8%, concern of potential drug-drug interactions related to antituberculous therapy in 23.2%, anemia in 13.9% of patients, and treatment failure in 6.7%.
Patients who discontinued and modified their cART regimens were classified as having discontinued cART, even if the modification occurred before the discontinuation.
Of the 1,554 study subjects, 830 (53%) discontinued cART for more than one month and 280 (18%) modified their cART regimens at least once.
In our study, 280 (28%) of 1,554 patients modified their cART regimens at least once during the follow-up (median 13 months).
The investigators modified the cART regimens based on drug resistance patterns in CSF and on CPE estimates, with the result that all responded with clinical improvement and reductions in HIV RNA in CSF.
(The restaurant sells them on the street at lunchtime, four for $5, from a bright-red modified hot dog cart).
A golf cart modified to look like the TV show's car went for $7,000.
In order to move about the grove, he slid along a board from his wheelchair into a golf cart modified to allow hand operations, handling the maneuver with military gruffness.
To compare survival probabilities between patients on cART and those who never started cART, the observation period for patients on cART was modified to start at the date when the patient first received cART and before TB diagnosis.
Auro's current prototypes are golf carts modified with laser scanners, radar, cameras, GPS, computers, and other components needed to steer themselves.
