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Moreover, other studies have shown that yeast PCNA is modified by small ubiquitin-like modifier (SUMO) on Lys164 and Lys127, and SUMOylated PCNA can recruit a helicase Srs2 to prevent undesired recombination (Pfander et al., 2005).
Many transcription factors and cofactors are modified by small ubiquitin-like modifier (SUMO).
SnoN is modified by small ubiquitin-like modifier-1 (SUMO-1) [ 55].
In addition, BRCA1 is also modified by small ubiquitin-related modifier (SUMO) in response to genotoxic damage.
Histone H4 is modified by small ubiquitin-related modifier (SUMO) family proteins both in vivo and in vitro.
It has been known that in mammalian cells, arrestin-3, which regulates internalization of β2-adrenergic receptor, is modified by small ubiquitin-like modifier protein (SUMO) at a lysine residue (Wyatt et al., 2011).
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Ptolemy's model was complex, with planetary orbits modified by smaller orbits (called epicycles), but it fit with observations, and could even be used to predict what the night sky would look like at an arbitrary date in the future.It is not known when the idea of a sun-centred cosmology came to Copernicus.
Here, we demonstrated that PTEN is also post-translationally modified by the small ubiquitin-like proteins, small ubiquitin-related modifier 1 (SUMO1) and SUMO2.
Previously, we demonstrated that Tec1, a transcription factor controlled by a MAP kinase Kss1 in yeast, is modified by a small ubiquitin-like modifier (SUMO) [19].
The MICOS complex may undergo only minor conformational changes due to the minor alterations generated by Aim24 modified by a small C-terminal tag.
Designed to take advantage of the Digital Equipment Corporation's brand-new PDP-1 minicomputer and the advent of a cathode-ray display screen, Spacewar was written before software was patented, and the original programmers' instructions were shared and freely modified by a small group of software designers.
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