Because the effects of adjuvant systemic therapy may be modified by certain prognostic characteristics, a number of treatment interaction terms were included in the model.
Notably, the data of Pischon et al. (15) suggest that the prognostic effect was modified by the presence of obesity.
In the present study, NLR levels did not correlate with MGMT promoter methylation status, and the prognostic role of NLR was not significantly modified by MGMT promoter methylation status, suggesting that these two prognostic factors may influence clinical outcome via different pathways and mechanisms (Tables 1, 2 and 3).
Despite showing promise as prognostic biomarkers, serum CRP and fibrinogen are not modified by potent inflammation modifying medications [ 38].
This indicates that the prognostic factors identified for the entire cohort were not modified by any of the interventions.
Moreover, the prognostic effect of serum albumin levels was not significantly modified by MGMT promoter methylation status, suggesting that these factors influence clinical outcome via different pathways.
The aim of this study was to investigate the prognostic prediction power of a newly introduced early warning score modified by serum lactate level, the National Early Warning Score Lactate (NEWS-L) score, among community-acquired pneumonia (CAP) patients.
The prognostic significance of any of these risk factors may be modified by the presence or absence of others [13] [22].
The strengths of our study reside in its multicentre design and the large number of patients as we were able to demonstrate the prognostic weight of the LVSI and the accuracy of the ESMO modified by the incorporation of LVSI.
Finally, the prognostic value of walking speed determined at baseline on mortality can be modified by intervening clinical and functional changes occurring during the follow-up.
