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We demonstrate that the accessibility of the pathways and the mechanisms of ligand exchange were modified by mutations.
That arginine reporter construct was now modified by mutations in the ligand-binding pocket and shortened in the linker between the chromophores and QBP.
Whether using the base VEGFR ePD model or those modified by mutations, the frequency of drug administration was characterized by both near-continuous and discontinuous drug administrations.
Risk associated with mono- ortho PCBs was slightly higher for tumors with mutations in the p53 gene but was not modified by mutations in K- ras.
The agonist affinity can be modified by mutations that cause a structural change in the binding site, or when an agonist-specific binding residue is altered.
The S1/S2 cleavage site and surrounding residues of serotype 1 FIPV S sequences were found to be systematically modified by mutations.
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It should be noted that the positional assignment of vibrational bands needs special care if protein structures are modified by mutation.
Because the anomaly had a significantly different prevalence among the offspring of three affected bulls, it is suspected that the trait has variable expressivity and/or the mutation is modified by other mutations, rather than being a simple recessive trait with complete penetrance.
The mechanical stability of a protein can be modified by introducing mutations in specific locations; however, introducing mutations is not reversible and the effect generally goes in the destabilizing direction.
Although all the four DNA bases can be modified by ROS, mutations mainly involve modification of GC base pairs, while AT base pair mutations are rarely observed [ 35].
The amino-acid sequence of a protein, and hence its function, can be modified by inducing mutations in the nucleotide sequence of its gene.
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