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We further examined whether or not the associations were modified by menopausal status and alcohol consumption.
This negative result was not modified by menopausal hormone use or diabetes mellitus (Table 3).
This association was modified by menopausal status with HRT (Pinteraction = 0.049) and seemed to be more pronounced in premenopause.
Associations between physical activity and mortality were not modified by menopausal status, comorbidity or body size, which was assessed ∼6 months after diagnosis.
Not only incidence rates differ according to menopausal status, but effects of some risk factors are also modified by menopausal status.
CYP17 c.1-34T>C was not associated with breast cancer risk overall, a result that did not seem to be modified by menopausal hormone use or diabetes mellitus.
Similar(48)
Associations with the SNPs evaluated in this report were not significantly modified by age, menopausal status, first degree family history of breast or ovarian cancer, or number of lifetime ovulatory cycles (data not shown).
Other subgroup analyses in the papers included in our review have suggested that the association between GL and endometrial cancer may be modified by diabetes, menopausal status, HRT use or physical activity (Augustin et al, 2003a; Folsom et al, 2003; Silvera et al, 2005; Cust et al, 2007a; Larsson et al, 2007).
The association with alcohol consumption was not modified by oral contraceptive use, hormone replacement therapy, parity, menopausal status, folate intake, body mass index, or smoking.
Furthermore, we examined whether this association is modified by hormone receptor status of the tumours and menopausal hormone therapy use at diagnosis.
In post-menopausal women, this risk may be modified by moderate intensity exercise at or above the recommended level (8 MET h per week per year).
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