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Considering that estradiol (E2) and n-3 polyunsaturated fatty acids (PUFAs) have roles in neurogenesis and in neurotransmission, we examined whether the association of PUFAs with incident depressive symptoms in postmenopausal women is modified by hormone therapy (HT) use or estrogen status.
The association of total fat intake with ovarian cancer may be modified by hormone and reproductive factors such as parity and oral contraceptive use.
It was not modified by hormone receptor status or by the use of anti-oestrogen therapy and was not observed in participants who reported HFs.
Furthermore, we examined whether this association is modified by hormone receptor status of the tumours and menopausal hormone therapy use at diagnosis.
In the present study, leptin levels did not differ with the use of postmenopausal hormone therapy, and neither was the association between plasma leptin concentration and mammographic density modified by hormone use (categorized as current use/non-current use; P for interaction = 0.23).
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In line with this, recent data have shown that CD154 expression could be modified by hormones such as estrogens [ 48] and prolactin [ 49].
This negative result was not modified by menopausal hormone use or diabetes mellitus (Table 3).
CYP17 c.1-34T>C was not associated with breast cancer risk overall, a result that did not seem to be modified by menopausal hormone use or diabetes mellitus.
These findings suggest that TYMS polymorphisms may be potential genetic markers of breast cancer risk modified by reproductive hormone levels of the subjects in their lifetime as indicated in menarche age, first live birth age, and menopausal status.
Leflunomide (LEF) is a disease-modifying antirheumatic drug used for treating rheumatoid arthritis (RA) and the action of which may be modified by sex hormones.
Indeed, glial ensheathing of neurons is modified by specific hormones, thus determining the availability of neuronal membrane space for synaptic inputs, with the loss of this plasticity possibly being involved in pathological processes.
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