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Although elemental incorporation rates can be modified by exogenous and endogenous factors including temperature, growth rate and physiological status [41] [43], these effects are typically small in magnitude compared to those driven by the large gradients in dissolved ambient concentrations between fresh and marine habitats.
And, it has been shown that RNAs can become modified by exogenous chemicals introduced into the cellular milieu.
The DNA methylome undergoes programmed changes during cellular differentiation, but it can be also modified by exogenous stimuli such as the diet and environmental factors, some of which are of the same typology as known atherosclerosis risk factors [ 3, 4].
Indeed, transgenesis of α-syn induced by viral overexpression in the nigro-striatum, induces dystrophic terminals in the striatum containing α-syn aggregates, which are not modified by exogenous administration of GDNF [ 146, 147].
In the present study, we evaluate if the onset of the disease can be modified by exogenous treatment with cytokines known to act synergistically in promoting a proinflammatory response [ 29], in order to better clarify the role of immune cells in scrapie in the central nervous system of mice.
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These animal studies – one placing mice adjacent to a Southern California highway [6] – reported a range of effects relevant to atherogenesis and significant progression of atherosclerosis, which was possibly modified by endogenous or exogenous factors such as genetics and diet [7].
In the present version of the model, the threshold level is modified by in an exogenous way but, as it has been observed, it is likely to be itself under genetic control.
A genetically modified organism (GMO) is defined as a living organism whose genome has been modified by the introduction of an exogenous gene able to express an additional protein that confers new characteristics, such as enhancement of the nutritional properties, herbicide resistance or insect protection.
Therefore, the association between smoking and breast cancer is possibly modified by other factors such as exogenous hormones.
In phase I, an exogenous molecule is modified by the addition of a functional group such as a hydroxyl, a carboxyl, or a sulfhydryl.
However, when Suzuki and colleagues (2010) followed up 50,757 Japanese women (aged 40 to 69) over 13 years, they found that breast cancer risk increased 6percentt with every additional 10 grams per day of alcohol consumption, but the observed association was not modified by menopausal status or use of exogenous estrogens.
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