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The cancer-promoting functions of versican may act through regulating growth factor activity and by interacting with immune and stromal cells [43], functions which could be modified by alterations to sulfation.
The responses of neocortical neurons can be persistently modified by alterations in sensory experience.
These results suggest that the biology of CRC cells can be modified by alterations in the tumour microenvironment under conditions of tumour hypoxia.
These observations lend support to the theory that the responses of neocortical neurons can be persistently modified by alterations in visceral sensory experience.
They are likely to have some degree of pneumococcal immunity through natural exposure, but this will have been modified by alterations of both the innate and acquired immune system related to HIV infection.
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These data indicate that the biology of solid tumours can be significantly modified by alteration of growth factor status.
The former can however also be influenced by circumstances where the associated pressure gradient is modified by significant alterations in right and/or left ventricular loading [ 38, 39].
These glycoproteins have some O-linked and/or N-linked glycans, and are modified by some glycosyltransferases via alteration of their susceptibility to galectin-1-induced apoptosis [ 47, 48].
However, as discussed in the following sections tonic contractile responses to cholinergic stimulation with carbachol where significantly altered by the cholesterol diet and tegaserod treatment, and these alterations were further modified by TTX and hexamethonium.
Changes in local HbO2 and HbT concentrations are representative of alterations in regional cerebral blood flow (rCBF) and oxygen delivery [ 24 26], while changes in the local HHb concentration, responses for which were not modified by TRNS, are more sensitive to alterations in the regional cerebral metabolic rate of oxygen consumption (rCMRO2) [ 27].
Whether muscle regeneration in aged mice is modified by changes in the extrinsic environment or by alterations of the satellite cells themselves is still a controversial issue.
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