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The association was stronger in men and at younger ages and was not modified by alcohol consumption or BMI.
Although we observed that rs1229984 A-allele carriers had higher triglyceride levels (1.6% (0.7% to 2.6%)), this effect was not modified by alcohol categories (fig 1 ).
We also further tested whether the association between folate intake and breast cancer risk could be modified by alcohol consumption that negatively regulates folate absorption and metabolism.
As alcohol consumption may negatively influence folate status and metabolism, we further tested whether the association between folate intake and breast cancer risk can be modified by alcohol assumption status.
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In addition, such studies could reveal the pathways that are modified by moderate alcohol consumption to enhance immune response to vaccination.
It is also reported that the associations between rs1665650, rs3824999 and colorectal cancer are not strongly modified by gender, alcohol, smoking, aspirin, and various dietary factors [ 30].
Interestingly, the human homologues of many of the genes epigenetically modified by acute alcohol administration in mice are involved in neurologic pathologies like Alzheimer disease (APP), ALS-Parkinson (TRPM7), myotonic dystrophy (DMPK), Angelman syndrome (UBE3A), and others.
Our data suggest that the risk for breast cancer among BRCA1 or BRCA2 carriers may be modified by reproductive characteristics and alcohol use.
We further examined whether or not the associations were modified by menopausal status and alcohol consumption.
In order to assess if the effect of the studied polymorphisms is modified by tobacco smoking and alcohol consumption, we performed a stratified logistic regression analysis.
4 In this study, we therefore investigated whether polymorphisms in the DNA BER genes (XRCC1 G399andnd OGG1 C326G) are associated with CCA risk and whether their effects are modified by cigarette smoking and alcohol drinking in a Northeastern Thai population residing in a high-incidence area of opisthorchiasis-related CCA.
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