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In addition, reports that KXGS motifs in tau species purified from NFTs are ubiquitinated [ 38, 42] indicate that these KXGS motifs are not acetylated, consistent with the notion that tau species modified by acetylation on KXGS motifs do not aggregate into NFTs.
Histone proteins can be chemically modified by acetylation, methylation, phosphorylation, and ubiquitylation [12], changing their configuration and in turn the shape of the nucleosome from closed (e.g., acetylated) to open (e.g., deacetylated).
Endogenous SOD2 is modified by acetylation.
Further, Nab3 was found to be posttranslationally modified by acetylation.
Few lysine residues can be either methylated or modified by acetylation, but never both together [ 2].
Histones can be modified by acetylation, methylation, phosphorylation, sumoylation, and ubiquitination.
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In addition, certain lysines may be modified by either acetylation or methylation.
GATA2 may be modified by phosphorylation, acetylation and sumoylation and is rapidly turned over by ubiquitination (Towatari et al, 1995; Hayakawa et al, 2004; Minegishi et al, 2005).
In addition, we have looked through the UCSC genome database, and found that the promoter region of OS9 may be modified by H3K27 acetylation.
The N-terminal tails of each histone extend outward through the DNA strand containing amino acid residues modified by posttranslational acetylation, methylation, and phosphorylation.
FOXO3a is modified by phosphorylation, acetylation and ubiquitination, which in turn affect its nuclear/cytoplasm shuttling, transcriptional activity and stability [ 43- 46].
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