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This new pharmacological paradigm suggests that multiple signaling pathways can be differentially modified by a single ligand-receptor interaction.
This would indicate STIM1 is modified by a single ubiquitin moiety.
The glycopeptides studied here are modified by a single GalNAc unit.
So-obtained GTVs were manually modified by a single radiation oncologist to reduce interobserver variability [ 25].
In Prochlorococcus MIT9313, 29 different peptide substrates are modified by a single promiscuous enzyme, ProcM, forming the characteristic thioether rings.
All GTVs were delineated with an autosegmentation tool using threshold −750 to 4096 Hu first then manually modified by a single radiation oncologist.
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Proteins can be modified by either a single ubiquitin moiety or polymeric ubiquitin chains to alter their stability, localization, binding partners, or physical conformation [1], [2].
To further verify that DUBs are modified by only a single ISG15VS probe per molecule, we replaced the catalytic cysteine at position 114 in USP14 with a serine residue.
They considered multiplicative neutrality function (Mani et al., 2008) and computed it using reporter levels of pairs of single mutants, modified by a Hill function to account for the saturation of the reporter signal.
In fact, he used exactly the same line in his address to Congress, modified only by a single word: "more".
The Smf1-SA mutant was less ubiquitinated than the wild-type Smf1, and seemed to be modified predominantly by a single ubiquitin.
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CEO of Professional Science Editing for Scientists @ prosciediting.com