We developed a method based on a modified broad-range PCR and an oligonucleotide microarray for the simultaneous detection and identification of 19 sepsis-causing pathogens at species level, as well as coagulase-negative staphylococci and Enterobacteriaceae at taxon level.
Cells typically add the H3K4me3 tags to histones in small sections of the genome, but researchers noticed that sometimes the tag can sprawl across much larger areas, modifying broad swaths of histones.
Thus, structural variations that impact on the functions of these proteins have potential to modify broad transcriptional activities and metabolism.
Broadly these can be considered as either programmes that work with individuals or in small groups to support smoking cessation, and approaches that modify broad population health interventions to more specifically target disadvantaged groups.
"Allele-specific" inhibitors that selectively target the sensitized PTP can be synthesized by modifying broad-specificity inhibitors with bulky chemical groups that are incompatible with wild-type PTP active sites; alternatively, specific inhibitors that serendipitously recognize the sensitized PTP's non-natural pocket may be discovered from panels of "non-rationally" designed compounds.
The scales on the ventral surface of the body are modified into broad plates in the majority of species and are used in locomotion.
In this study, dialogic reading was modified for broad dissemination through four branches of a city library system.
Open image in new window Fig. 3 Generalised chronostratigraphy and sequence stratigraphy of Orange Basin offshore Mesozoic basin showing sample locations, based on results of sequence stratigraphic studies (modified after Broad et al. 2006).
Open image in new window Fig. 1 Map of the offshore wells distribution in the Orange Basin, insert is the map of South Africa showing the position of the basin (modified from Broad 2004) Open image in new window Fig. 2 Stratigraphy and seismic horizons of the South-west African offshore (Orange Basin) (modified from Light et al. 1993).
All isoforms present a cytoplasmic localization and their degradation was neither modified by broad-spectrum kinase or phosphatase inhibitors such as staurosporine or okadaic acid nor by specific inhibition of several intracellular signalling pathways including Erk, Akt and mTORC1.
Although the justices have been eager to expand their own power in relation to that of Congress and the president, they have been reluctant to strike down or modify excessively broad laws adopted in haste after especially dramatic or horrific events.
